N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine
UK-371804
CAS: 256477-09-5
Molecular Formula: C14H16ClN5O4S
N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine - Names and Identifiers
N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine - Physico-chemical Properties
| Molecular Formula | C14H16ClN5O4S |
| Molar Mass | 385.83 |
| Solubility | DMSO: 10 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
| In vivo study | In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM. |
N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.592 ml | 12.959 ml | 25.918 ml |
| 5 mM | 0.518 ml | 2.592 ml | 5.184 ml |
| 10 mM | 0.259 ml | 1.296 ml | 2.592 ml |
| 5 mM | 0.052 ml | 0.259 ml | 0.518 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: UK-371804 Visit Supplier Webpage Request for quotationCAS: 256477-09-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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